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methyl-β-cyclodextrin (mβcd, t4072)  (Target Molecule Corp)

 
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    Target Molecule Corp methyl-β-cyclodextrin (mβcd, t4072)
    Methyl β Cyclodextrin (Mβcd, T4072), supplied by Target Molecule Corp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/methyl-%CE%B2-cyclodextrin+(m%CE%B2cd%2C+t4072)/methyl+%CE%B2+cyclodextrin++m%CE%B2cd++t4072+/pmc09785492-56-9-18
    Average 90 stars, based on 1 article reviews
    methyl-β-cyclodextrin (mβcd, t4072) - by Bioz Stars, 2026-09
    90/100 stars

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    Article Snippet: Nisoldipine (T0163), cilnidipine (T0388), nitrendipine (T0119), nimodipine (T0343) and methyl-β-cyclodextrin (MβCD, T4072) with 98% purity were purchased from Target Molecule Corp (Shanghai, China).



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    BCoV <t>requires</t> <t>cholesterol</t> to enter HRT-18 cells. ( A ) The maximum safe concentrations of <t>MβCD</t> were determined using the CCK-8 assay. ( B ) Western blot analysis was used to evaluate the BCoV N protein expression levels, with grayscale analysis performed and presented as a bar graph. ( C ) RT-qPCR was performed to assess the BCoV gene copy numbers. ( D ) TCID 50 assay was used to measure the BCoV viral titers in the cell supernatant. ( E ) IFA was used to detect the number of BCoV-infected cells. Scale bar = 100 µm. ( F ) RT-qPCR was used to evaluate the effect of MβCD on the viral entry. ( G ) RT-qPCR was used to evaluate the effect of MβCD on the viral attachment. Data are presented as the mean ± SD of three independent experiments (not significant, P > 0.05; * P < 0.05; ** P < 0.01; *** P < 0.001).
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    BCoV <t>requires</t> <t>cholesterol</t> to enter HRT-18 cells. ( A ) The maximum safe concentrations of <t>MβCD</t> were determined using the CCK-8 assay. ( B ) Western blot analysis was used to evaluate the BCoV N protein expression levels, with grayscale analysis performed and presented as a bar graph. ( C ) RT-qPCR was performed to assess the BCoV gene copy numbers. ( D ) TCID 50 assay was used to measure the BCoV viral titers in the cell supernatant. ( E ) IFA was used to detect the number of BCoV-infected cells. Scale bar = 100 µm. ( F ) RT-qPCR was used to evaluate the effect of MβCD on the viral entry. ( G ) RT-qPCR was used to evaluate the effect of MβCD on the viral attachment. Data are presented as the mean ± SD of three independent experiments (not significant, P > 0.05; * P < 0.05; ** P < 0.01; *** P < 0.001).
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    BCoV <t>requires</t> <t>cholesterol</t> to enter HRT-18 cells. ( A ) The maximum safe concentrations of <t>MβCD</t> were determined using the CCK-8 assay. ( B ) Western blot analysis was used to evaluate the BCoV N protein expression levels, with grayscale analysis performed and presented as a bar graph. ( C ) RT-qPCR was performed to assess the BCoV gene copy numbers. ( D ) TCID 50 assay was used to measure the BCoV viral titers in the cell supernatant. ( E ) IFA was used to detect the number of BCoV-infected cells. Scale bar = 100 µm. ( F ) RT-qPCR was used to evaluate the effect of MβCD on the viral entry. ( G ) RT-qPCR was used to evaluate the effect of MβCD on the viral attachment. Data are presented as the mean ± SD of three independent experiments (not significant, P > 0.05; * P < 0.05; ** P < 0.01; *** P < 0.001).
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    BCoV requires cholesterol to enter HRT-18 cells. ( A ) The maximum safe concentrations of MβCD were determined using the CCK-8 assay. ( B ) Western blot analysis was used to evaluate the BCoV N protein expression levels, with grayscale analysis performed and presented as a bar graph. ( C ) RT-qPCR was performed to assess the BCoV gene copy numbers. ( D ) TCID 50 assay was used to measure the BCoV viral titers in the cell supernatant. ( E ) IFA was used to detect the number of BCoV-infected cells. Scale bar = 100 µm. ( F ) RT-qPCR was used to evaluate the effect of MβCD on the viral entry. ( G ) RT-qPCR was used to evaluate the effect of MβCD on the viral attachment. Data are presented as the mean ± SD of three independent experiments (not significant, P > 0.05; * P < 0.05; ** P < 0.01; *** P < 0.001).

    Journal: Journal of Virology

    Article Title: Bovine coronavirus enters HRT-18 cells via membrane fusion and clathrin-mediated endocytosis in a low pH-, dynamin-, cholesterol-, microtubule-, Rab7-, and Rab11-dependent manner

    doi: 10.1128/jvi.01274-25

    Figure Lengend Snippet: BCoV requires cholesterol to enter HRT-18 cells. ( A ) The maximum safe concentrations of MβCD were determined using the CCK-8 assay. ( B ) Western blot analysis was used to evaluate the BCoV N protein expression levels, with grayscale analysis performed and presented as a bar graph. ( C ) RT-qPCR was performed to assess the BCoV gene copy numbers. ( D ) TCID 50 assay was used to measure the BCoV viral titers in the cell supernatant. ( E ) IFA was used to detect the number of BCoV-infected cells. Scale bar = 100 µm. ( F ) RT-qPCR was used to evaluate the effect of MβCD on the viral entry. ( G ) RT-qPCR was used to evaluate the effect of MβCD on the viral attachment. Data are presented as the mean ± SD of three independent experiments (not significant, P > 0.05; * P < 0.05; ** P < 0.01; *** P < 0.001).

    Article Snippet: The inhibitors used in this study included SSAA09E3 (Cat HY-138102, MedChemExpress), a novel inhibitor that blocks the fusion of the viral membrane with the host cell membrane; CPZ (Cat C0982, Sigma), a clathrin-mediated endocytosis inhibitor; nystatin (Cat 475914, Sigma), a caveolae inhibitor that acts as a sterol-binding agent disrupting caveolae; blebbistatin (Cat 203391, Sigma), an inhibitor of micropinocytosis; dynasore (Cat T1848, TargetMol), a dynamin inhibitor; MβCD (Cat T4072, TargetMol), a cholesterol depletion inhibitor; chloroquine (Cat S6999, Selleck) and NH 4 Cl (Cat A9434, Sigma), a potent inhibitor of V-ATPase and a specific inhibitor of acidification of endosomal vesicles; colchicine (Cat HY-16569, MedChemExpress), which inhibits the polymerization of tubulin; E64d (Cat S7393, Selleck), a cathepsin inhibitor; and camostat (Cat HY-13512, MedChemExpress), a TMPRSS2 inhibitor.

    Techniques: CCK-8 Assay, Western Blot, Expressing, Quantitative RT-PCR, Infection